De voornaamste CYP-iso-enzymen, met hun voornaamste substraten, inhibitoren en inductoren
De meest krachtige inhibitoren en inductoren zijn in vet gedrukt.
| |
Substraten |
Inhibitoren |
Inductoren |
| CYP1A2 |
Clozapine, coffeïne, duloxetine,
imipramine, olanzapine, rasagiline,
ropinirol, theofylline, tizanidine |
Cimetidine, ciprofloxacine,
fluvoxamine, ticlopidine |
Barbituraten, carbamazepine,
fenytoïne, primidon, rifabutine,
rifampicine, sigarettenrook |
| CYP2C8 |
Pioglitazon, repaglinide, rosiglitazon |
Trimethoprim |
Rifampicine |
| CYP2C9 |
Fenytoïne, fluvastatine, S-warfarine |
Amiodaron, cimetidine,
fenylbutazon, fluconazol,
fluvoxamine, isoniazide, miconazol,
sulfamethoxazol, voriconazol,
zafirlukast |
Barbituraten, carbamazepine,
fenytoïne, primidon, rifampicine,
ritonavir |
| CYP2C19 |
Citalopram, clomipramine,
diazepam, esomeprazol, fenytoïne,
omeprazol, proguanil |
Cimetidine, esomeprazol,
fluoxetine, fluvoxamine,
omeprazol, ticlopidine |
Fenobarbital, fenytoïne |
| CYP2D6 |
Anti-aritmica: flecaïnide,
mexiletine, propafenonAntidepressiva:
amitriptyline, clomipramine,
desipramine, duloxetine,
imipramine, nortriptyline,
paroxetine, venlafaxineAntipsychotica: aripiprazol,
haloperidol, risperidon,
zuclopenthixolβ-blokkers: metoprolol,
timololVaria: codeïne,
darifenacine,
dextromethorfan,
fesoterodine, tramadol |
Amiodaron, bupropion, cimetidine,
duloxetine, fluoxetine, kinidine,
lumefantrine, paroxetine,
propafenon, ritonavir,
terbinafine |
Geen gekend |
| CYP3A4 |
Anti-aritmica: amiodaron,
disopyramide, kinidine,
lidocaïne Anti-infectieuze middelen:
clarithromycine, efavirenz,
erythromycine, fluconazol,
itraconazol, ketoconazol,
nevirapine, de
protease-inhibitorenBenzodiazepines:
alprazolam, diazepam,
midazolam, triazolamCalciumantagonisten:
dihydropyridines, diltiazem,
verapamilStatines: atorvastatine,
simvastatineVaria: alfentanil, aprepitant,
aripiprazol, bortezomib,
budesonide, buspiron,
busulfan, carbamazepine,
ciclosporine, cisapride,
darifenacine,
dexamethason,
dihydro-ergotamine,
elitriptan, ergotamine,
erlotinib, ethinylestradiol,
everolimus, fesoterodine,
haloperidol, imatinib,
irinotecan, ivabradine,
lumefantrine, maraviroc,
methadon,
methylprednisolon,
pimozide, quetiapine,
reboxetine, repaglinide,
sibutramine, sildenafil,
sirolimus, solifenacine,
tacrolimus, tadalafil,
theofylline,
tyrosinekinase-inhibitoren,
tramadol, trazodon,
vardenafil, Vinca
rosea-afgeleiden |
Amiodaron, aprepitant, cimetidine,
ciprofloxacine, clarithromycine,
diltiazem, erythromycine,
fluconazol, fluoxetine, fluvoxamine,
imatinib, itraconazol,
ketoconazol, norfloxacine,
pompelmoessap, de
protease-inhibitoren,
telithromycine, verapamil,
voriconazol |
Barbituraten, carbamazepine,
efavirenz, fenytoïne, nevirapine,
oxcarbazepine, primidon, rifabutine,
rifampicine, Sint-Janskruid,
topiramaat |
| Naar o.a. www.drug-interactions.com; www.medicine.iupui.edu/flockhart;
www.hiv-druginteractions.org; Tijdschr Geneesk 2002;58:710-7; Commentaren
Medicatiebewaking 2007-2008 (Pharmacom/Medicom); The Top 100 Drug Interactions 2007
(Hansten and Horn, H & H Publications); themanummer "Interactions
Médicamenteuses/Comprendre et décider”: La Revue Prescrire (december 2007) |
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