Tabel If. De CYP-iso-enzymen, met hun voornaamste substraten, inhibitoren en inductoren
De meest krachtige inhibitoren en inductoren zijn vetjes gedrukt.
| |
Substraten |
Inhibitoren |
Inductoren |
| CYP1A2 |
Clozapine, coffeïne, duloxetine,
imipramine, melatonine, olanzapine,
rasagiline, ropinirol, theofylline,
tizanidine |
Cimetidine, ciprofloxacine,
fluvoxamine, ticlopidine |
Barbituraten, carbamazepine, fenytoïne, primidon, rifabutine, rifampicine, sigarettenrook |
| CYP2C8 |
Pioglitazon, repaglinide, rosiglitazon |
Trimethoprim |
Rifampicine |
| CYP2C9 |
Fenytoïne, fluvastatine, S-warfarine |
Amiodaron, cimetidine,
fenylbutazon, fluconazol,
fluvoxamine, isoniazide, miconazol,
sulfamethoxazol, voriconazol,
zafirlukast |
Barbituraten, carbamazepine, fenytoïne, primidon, rifampicine, ritonavir |
| CYP2C19 |
Citalopram, clomipramine,
clopidogrel, diazepam,
esomeprazol, fenytoïne, omeprazol,
proguanil |
Cimetidine, esomeprazol,
fluoxetine, fluvoxamine,
omeprazol, ticlopidine |
Fenobarbital, fenytoïne |
| CYP2D6 |
Anti-aritmica: flecaïnide,
mexiletine, propafenonAntidepressiva: amitriptyline,
clomipramine, desipramine,
duloxetine, imipramine,
nortriptyline, paroxetine,
venlafaxineAntipsychotica: aripiprazol,
haloperidol, risperidon,
zuclopenthixolβ-blokkers: metoprolol,
timololVaria: codeïne, darifenacine,
dextromethorfan,
fesoterodine, tramadol |
Amiodaron, bupropion, cimetidine,
duloxetine, fluoxetine, kinidine,
lumefantrine, paroxetine,
propafenon, ritonavir,
terbinafine |
Geen gekend |
| CYP3A4 |
Anti-aritmica: amiodaron, disopyramide, kinidine, lidocaïne Anti-infectieuze middelen:
clarithromycine, efavirenz, erythromycine, fluconazol, itraconazol, ketoconazol, nevirapine, de
protease-inhibitoren
Benzodiazepines: alprazolam, diazepam, midazolam, triazolam
Calciumantagonisten: dihydropyridines, diltiazem, verapamil
Statines: atorvastatine, simvastatine
Varia: alfentanil, alkaloïden van Vinca rosea, aprepitant, aripiprazol, bortezomib,
budesonide, buspiron,
busulfan, carbamazepine,
ciclosporine, cisapride,
colchicine, darifenacine,
dexamethason,
dihydro-ergotamine,
elitriptan, ergotamine,
erlotinib, ethinylestradiol,
everolimus, fesoterodine,
haloperidol, imatinib,
irinotecan, ivabradine,
lumefantrine, maraviroc,
methadon,
methylprednisolon, nilotinib,
pimozide, quetiapine,
reboxetine, repaglinide,
rivaroxaban, sibutramine,
sildenafil, sirolimus,
solifenacine, tacrolimus,
tadalafil, temsirolimus,
theofylline,
tyrosinekinase-inhibitoren,
tramadol, trazodon,
vardenafil |
Amiodaron, aprepitant, cimetidine,
ciprofloxacine, clarithromycine,
diltiazem, erythromycine,
fluconazol, fluoxetine, fluvoxamine,
imatinib, itraconazol,
ketoconazol, norfloxacine,
pompelmoes/pomelo,
posiconazol, de
protease-inhibitoren,
telithromycine, verapamil,
voriconazol |
Barbituraten, carbamazepine,
efavirenz, fenytoïne, nevirapine,
oxcarbazepine, primidon, rifabutine,
rifampicine, Sint-Janskruid,
topiramaat |
| Naar o.a. www.drug-interactions.com; www.medicine.iupui.edu/flockhart;
www.hiv-druginteractions.org; Tijdschr Geneesk 2002;58:710-7; Commentaren
Medicatiebewaking 2007-2008 (Pharmacom/Medicom); The Top 100 Drug Interactions
2007 (Hansten and Horn, H & H Publications); themanummer "Interactions
médicamenteuses/Comprendre et décider”: La Revue Prescrire (december 2007) |
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